Xenograft and organoid model systems in cancer research
نویسندگان
چکیده
منابع مشابه
In vivo opossum xenograft model for cancer research.
The inadequacies of athymic mice for research with grafted tumors are well known. Monodelphis domestica, the laboratory opossum, has the potential to complement the rodent model because of the immunoincompetent window period during early marsupial development. We injected pups of different ages with mouse melanoma cells and human melanoma, colon, and prostate cancer cells. The results showed th...
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Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ three-dimensional (3D) culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into 3D structures. These systems evolved, methodologically and conceptually, from classical reaggregat...
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Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2019
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2019101654